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Receptor family
|
Cluster of Designation
|
Ligands
|
|---|
|
Activating receptors
| | |
|
T cell receptor complex
|
CD3
|
MHC:peptide
|
|
Co-receptors
| | |
|
CD2
|
CD 2
|
CD58
|
|
CD4
|
CD4
|
MHC class II
|
|
CD5
|
CD5
|
CD72 (?)
|
|
CD8
|
CD8
|
MHC class I
|
|
CD27
|
CD27
|
CD70
|
|
Activating receptors
| | |
|
CD28
|
CD28
|
B7.1 (CD80), B7.2 (CD86), B7H2 (CD275)
|
|
OX40
|
CD134
|
OX40L (CD252)
|
|
4-1-BB
|
CD137
|
CD137L
|
|
CD40L
|
CD154
|
CD40
|
|
DNAM-1
|
CD226
|
PVR (CD155), PVR2 (CD112)
|
|
TACI
|
CD267
|
BAFF (CD257), APRIL (CD256)
|
|
BCMA
|
CD269
|
BAFF (CD257), APRIL (CD256)
|
|
ICOS
|
CD278
|
B7H2 (CD275)
|
|
GITR
|
CD357
|
GITRL (-)
|
|
BAFFR
|
n/a
|
BAFF (CD257)
|
|
Inhibitory receptors
| | |
|
B7.1
|
CD80
|
PDL-1 (CD274), CD28, CTLA4 (CD152)
|
|
CTLA4
|
CD152
|
B7.1(CD80), B7.2(CD86), B7H2 (CD275)
|
|
CD160
|
CD160
|
HVEM (-)
|
|
CD200R
|
CD200R
|
CD200
|
|
LAG-3
|
CD223
|
MHC class II, other?
|
|
2B4
|
CD244
|
CD48
|
|
LIGHT
|
CD258
|
HVEM (-)
|
|
BTLA
|
CD272
|
HVEM (-)
|
|
PDL-1
|
CD274
|
PD-1 (CD279)
|
|
PD-1
|
CD279
|
PD-L1 (CD274), PDL-2 (CD273)
|
|
TIM-3
|
n/a
|
Galectin-9 (-), other?
|
|
TIGIT
|
n/a
|
PVR (CD155), PVR2 (CD112)
|
|
VISTA (PD-1H)
|
n/a
|
B7H4 (-), other?
|
|
B7H4
|
n/a
|
Unknown
|
|
KLRG-1
|
n/a
|
E-Cadherin (CD324)
|
